a synthetic acetylated peptide corresponding to residues surrounding Lys49 of human β-catenin protein
Conjugate
Unconjugated
Applications
Application Notes
WB 1:1000; IP 1:200
Product Background
Antigen Description
β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines. Lys49 lies in a region that contains several Ser/Thr residues whose phosphorylation status regulates the stability of β-catenin. Research studies have shown that Lys49 is one of few residues frequently mutated in thyroid anaplastic carcinoma. CREB-binding protein (CBP) binds and acetylates β-catenin at Lys49.
Citations
Publication ()
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