Anti-ACACA monoclonal antibody (DCABH-233)

Rabbit anti-Human ACACA monoclonal antibody for WB, IP, IHC-P, ICC Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS4254Z
Species Reactivity
Human
Immunogen
A synthetic peptide corresponding to residues surrounding serine 221 of Human Acetyl Coenzyme A Carboxylase.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/10000; IP: 1/10; IHC-P: 1/100 - 1/250; ICC: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ACACA; acetyl-CoA carboxylase alpha; ACAC, ACC, acetyl Coenzyme A carboxylase alpha; acetyl-CoA carboxylase 1; ACC1; acetyl CoA carboxylase 1
Entrez Gene ID
UniProt ID

Product Background


Pathway
AMPK signaling, organism-specific biosystem; ChREBP activates metabolic gene expression, organism-specific biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; Fatty Acyl-CoA Biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, conserved biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem;

Citations


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References


Griffith, DA; Kung, DW; et al. Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes. JOURNAL OF MEDICINAL CHEMISTRY 57:10512-10526(2014).
Gowans, GJ; Hardie, DG; et al. AMPK: a cellular energy sensor primarily regulated by AMP. BIOCHEMICAL SOCIETY TRANSACTIONS 42:71-75(2014).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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