General Notes
This product (Catalog No. DPABH-11495) is a rabbit-derived polyclonal antibody raised against human ATXN3, targeting the amino acid region 1–182 of the protein. It has been affinity purified by Protein A. Ataxin-3 is a protein with a molecular weight of 42 kDa that is found in both the nucleus and cytoplasm of cells. It functions as a deubiquitinating enzyme (DUB), cleaving ubiquitin from ubiquitinated substrates or poly-ubiquitin chains. It is also involved in transcriptional regulation, although the connection between these two roles is not yet understood. Ataxin-3 is implicated in the molecular pathogenesis of MJD/SCA3, where its dysfunction leads to the misfolding and aggregation of proteins in neurons.
DPABH-11495 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-11495 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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