Anti-ATP6V1E1 (aa 114-226) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human

Immunogen

Recombinant fragment corresponding to Human ATP6V1E1 aa 114-226. (BC004443).Sequence: VLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDV DVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRG ALFGANANRKFLD Database link: P36543 Run BLAST with Run BLAST with

Conjugate

Application Notes

IHC-P: 1/100 - 1/500; WB: 1/200 - 1/1000.

Alternative Names

ATP6V1E1; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1; ATP6E, ATP6V1E, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 31kD; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1; V-type proton ATPase subunit E 1; ATP6E2;

Entrez Gene ID

UniProt ID

Antigen Description

ATP6V1E1 is a component of vacuolar ATPase (V ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This protein is alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome.

Pathway

Collecting duct acid secretion; Epithelial cell signaling in Helicobacter pylori infection; Insulin receptor recycling; Iron uptake and transport; Metabolic pathways;