Anti-ATP6V1C1 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human ATP6V1C1 is used for rabbit immunization.

Conjugate

Unconjugated

Alternative Names

ATP6V1C1; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1; VATC; Vma5; ATP6C; ATP6D; V-type proton ATPase subunit C 1; V-ATPase C subunit; H+ -ATPase C subunit; V-ATPase subunit C 1; vacuolar proton pump C subunit; vacuolar ATP synthase subunit C;

Entrez Gene ID

528

UniProt ID

A0A024R9I0

Antigen Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.

Pathway

Collecting duct acid secretion; Collecting duct acid secretion; Disease; Epithelial cell signaling in Helicobacter pylori infection; Epithelial cell signaling in Helicobacter pylori infection; Insulin receptor recycling; Iron uptake and transport; Latent infection of Homo sapiens with Mycobacterium tuberculosis; Oxidative phosphorylation; Oxidative phosphorylation; Phagosomal maturation (early endosomal stage);

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More