Anti-ATP6V0C monoclonal antibody (DCABH-10676) Made to order

Rabbit anti-Human ATP6V0C monoclonal antibody for WB, ELISA

View other ATP6V0C antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ATP6V0C is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ATP6V0C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATP6C, ATP6L, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD , ATPL; V-type proton ATPase 16 kDa proteolipid subunit; VATL; Vma3
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ATP6V0C (ATPase H+ Transporting V0 Subunit C) is a Protein Coding gene. Diseases associated with ATP6V0C include progressive myoclonic epilepsy with dystonia and dravet syndrome. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include ubiquitin protein ligase binding and proton-transporting ATPase activity, rotational mechanism. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17.
Antigen Description
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c" , and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the V0 domain. This gene had the previous symbols of ATP6C and ATP6L. Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. V-type proton ATPase 16 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0C gene. The V0 domain consists of five different subunits: a, c, c, c", and d. The function about ATP6V0C antigen include hydrogen ion transporting ATP synthase activity, rotational mechanism; protein binding; proton-transporting ATPase activity, rotational mechanism; ubiquitin protein ligase binding.
Pathway
Collecting duct acid secretion, organism-specific biosystem; Collecting duct acid secretion, conserved biosystem; Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem; Insulin receptor recycling, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Lysosome, organism-specific biosystem.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Jin, HO; Lee, YH; et al. Inhibition of vacuolar H plus ATPase enhances sensitivity to tamoxifen via up-regulation of CHOP in breast cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 437:463-468(2013).
Lim, JH; Park, JW; et al. ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1 alpha (HIF-1 alpha) binding and mediates HIF-1 alpha expression by bafilomycin A1. MOLECULAR PHARMACOLOGY 71:942-948(2007).

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