Anti-ATP5H monoclonal antibody, clone 8G0CH2

Antibody Isotype

IgG2b

Clone

8G0CH2

Species Reactivity

Mouse; Rat; Cow; Human; African green monkey

Immunogen

Bovine Complex V

Conjugate

Application Notes

WB: 1 μg/ml; ICC/IF: 1 - 5 μg/ml; Flow Cyt: 1 μg/ml;

Alternative Names

ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d; ATP synthase subunit d, mitochondrial; ATPase subunit d; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d; MGC128531;

Entrez Gene ID

UniProt ID

Antigen Description

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Pathway

Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Electron Transport Chain, organism-specific biosystem; F-type ATPase, eukaryotes, organism-specific biosystem; Formation of ATP by chemiosmotic coupling, organism-specific biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem.