Anti-ATP5H monoclonal antibody (DCABH-273)

Mouse anti-Bovine ATP5H monoclonal antibody for WB, ICC/IF, FC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
8G0CH2
Species Reactivity
Mouse, Rat, Cow, Human, African green monkey
Immunogen
Bovine Complex V
Conjugate
Unconjugated

Applications


Application Notes
WB: 1 μg/ml; ICC/IF: 1 - 5 μg/ml; Flow Cyt: 1 μg/ml;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d; ATP synthase subunit d, mitochondrial; ATPase subunit d; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d; MGC128531
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ATP5H (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit D) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. GO annotations related to this gene include ATPase activity and hydrogen ion transmembrane transporter activity. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15.
Antigen Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. The human gene ATP5H encodes subunit d of the enzyme mitochondrial ATP synthase. 0The function about ATP5H antigen include hydrogen ion transmembrane transporter activity.
Pathway
Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Electron Transport Chain, organism-specific biosystem; F-type ATPase, eukaryotes, organism-specific biosystem; Formation of ATP by chemiosmotic coupling, organism-specific biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem.

Citations


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References


Li, RS; Zou, HF; et al. Glucocorticoid receptor is involved in the breed-dependent transcriptional regulation of mtDNA- and nuclear-encoded mitochondria genes in the liver of newborn piglets. BMC VETERINARY RESEARCH 9:-(2013).

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