Specifications
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S1981 of human ATM.
Applications
Application Notes
ELISA: 1:2000-1:10000; WB: 1:500-1:2000.; The optimal working dilution should be determined by the end user.
Target
Alternative Names
ATM; ATM serine/threonine kinase; AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; serine-protein kinase ATM; AT mutated; A-T mutated; ataxia telangiectasia mutated; TEL1, telomere maintenance 1, homolog;
Product Background
Antigen Description
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Pathway
ATM mediated phosphorylation of repair proteins; Apoptosis; BARD1 signaling events; Canonical NF-kappaB pathway
Citations
Publication ()
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COA
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