Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008]
Pathway
FoxO signaling pathway; Immune System; Innate Immune System; Negative regulators of RIG-I/MDA5 signaling; RIG-I-like receptor signaling pathway; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways; Regulation of autophagy; Senescence and Autophagy
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