This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
Pathway
ATF4 activates genes; ATF6-alpha activates chaperone genes; ATF6-alpha activates chaperones; Alzheimer's disease; Alzheimers Disease; Metabolism of proteins; PERK regulates gene expression; Protein processing in endoplasmic reticulum
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Huang, HY; Que, HP; et al. Preparation and Characterization of Murine Monoclonal Antibodies Against Rat Spinal Cord Injury and Regeneration Related Protein No. 69. HYBRIDOMA 28:27-31(2009).
Ku, SCY; Lwa, TR; et al. Identification of HUGT1 as a potential BiP activator and a cellular target for improvement of recombinant protein production using a cDNA screening system. MOLECULES AND CELLS 27:577-582(2009).
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