Anti-ATAD3B monoclonal antibody (DCABH-10651) Made to order

Rabbit anti-Human ATAD3B monoclonal antibody for WB, ELISA

View other ATAD3B antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ATAD3B is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ATAD3B; ATPase family, AAA domain containing 3B; ATPase family AAA domain-containing protein 3B; KIAA1273; TOB3; AAA-ATPase TOB3
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ATAD3B (ATPase Family, AAA Domain Containing 3B) is a Protein Coding gene. An important paralog of this gene is ATAD3A. The protein encoded by this gene is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expressed almost exclusively in pluripotent embryonic stem cells and some cancer cells. Two transcript variants encoding different isoforms have been found for this gene.
Antigen Description
ATAD3A (MIM 612316) and ATAD3B are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al. , 2007 [PubMed 17210950]). May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes. The function about ATAD3B antigen include ATP binding; nucleoside-triphosphatase activity; nucleotide binding.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Li, SJ; Lamarche, F; et al. Expression analysis of ATAD3 isoforms in rodent and human cell lines and tissues. GENE 535:60-69(2014).

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