Rabbit Anti-Human ASIP (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthesized peptide derived from human ASIP, corresponding to a region within the internal amino acids.

Conjugate

Application Notes

WB 1:1000-3000

General Notes

This product (Catalog No. DPABH-03187) is a rabbit-derived polyclonal antibody raised against human ASIP. It has been affinity purified by Protein A. Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
DPABH-03187 is suitable for use in WB 1 (1000-3000) application.
DPABH-03187 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Entrez Gene ID

UniProt ID