Anti-ASAP1 monoclonal antibody, clone 8C23

Antibody Isotype

IgG2b

Clone

8C23

Species Reactivity

Rat; Human

Immunogen

Recombinant fragment, corresponding to amino acids 977-1532 of Human ASAP1/ DDEF1 with N-terminal proprietary tag produced in E.coli strain BL-21.

Conjugate

Application Notes

WB: 1 μg/ml; IHC-P: 5 μg/ml; IHC-Fr: 5 μg/ml; IP: 10 μg/ml;

Alternative Names

ASAP1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1; DDEF1, development and differentiation enhancing factor 1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; centaurin; beta 4; CENTB4; KIAA1249; PAP; ZG14P; DEF-1; cent

Entrez Gene ID

UniProt ID

Antigen Description

Possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.

Pathway

Arf1 pathway, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; Signaling events mediated by focal adhesion kinase, organism-specific biosystem;