Anti-ARPC1B monoclonal antibody (DCABH-10616) Made to order

Rabbit anti-Human ARPC1B monoclonal antibody for WB, ELISA

View other ARPC1B antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ARPC1B is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa; actin related protein 2/3 complex, subunit 1B (41 kD); actin-related protein 2/3 complex subunit 1B; actin related protein 2/3 complex; subunit 1A (41 kD)
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ARPC1B (Actin Related Protein 2/3 Complex Subunit 1B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC1A. This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase.
Antigen Description
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Actin-related protein 2/3 complex subunit 1B is a protein that in humans is encoded by the ARPC1B gene. The function about ARPC1B antigen include actin binding; structural constituent of cytoskeleton.
Pathway
B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; CDC42 signaling events, organism-specific biosystem; ErbB1 downstream signaling, organism-specific biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Urzua, U; Roby, KF; et al. Transcriptomic analysis of an in vitro murine model of ovarian carcinoma: Functional similarity to the human disease and identification of prospective tumoral markers and targets. JOURNAL OF CELLULAR PHYSIOLOGY 206:594-602(2006).
Kusakabe, M; Kutomi, T; et al. Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches. INTERNATIONAL JOURNAL OF CANCER 126:1895-1902(2010).

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