Synthetic peptide within Human p114RhoGEF aa 90-119 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q6ZSZ5
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.
Pathway
Cell death signalling via NRAGE, NRIF and NADE; G alpha (12/13) signalling events; Loss of Function of SMAD2/3 in Cancer; Loss of Function of TGFBR1 in Cancer
Citations
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