Anti-ARHGEF18 monoclonal antibody, clone HU2083

Antibody Isotype

IgG2a

Clone

HU2083

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment within Human p114RhoGEF aa 612-832. The exact sequence is proprietary.Database link: Q6ZSZ5

Conjugate

Application Notes

WB: 1/500 - 1/3000;

Alternative Names

ARHGEF18; Rho/Rac guanine nucleotide exchange factor (GEF) 18; rho/rac guanine nucleotide exchange factor (GEF) 18; rho guanine nucleotide exchange factor 18; KIAA0521; MGC15913; P114 RhoGEF; Rho specific guanine nucleotide exchange factor p114; SA-RhoGEF

Entrez Gene ID

UniProt ID

Antigen Description

Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.

Pathway

Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; NRAGE signals death through JNK, organism-specific biosystem; Regulation of RhoA activity, organism-specific biosystem; Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem;