Anti-ARHGAP25 monoclonal antibody (DCABH-610)

Mouse anti-Human ARHGAP25 monoclonal antibody for WB, ICC/IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
5E9
Species Reactivity
Human
Immunogen
Recombinant full length protein of Human ARHGAP25 (NP_055697), produced in HEK293T cell.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ARHGAP25; Rho GTPase activating protein 25; rho GTPase-activating protein 25; KIAA0053; rho-type GTPase-activating protein 25; KAIA0053
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ARHGAP25 (Rho GTPase Activating Protein 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SRGAP3. ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).
Antigen Description
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. The function about ARHGAP25 antigen include GTPase activator activity.
Pathway
Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by Rho GTPases, organism-specific biosystem.

Citations


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References


Gohla, A; Harhammer, R; et al. The G-protein G(13) but not G(12) mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. JOURNAL OF BIOLOGICAL CHEMISTRY 273:4653-4659(1998).
CHENG, JC; FRACKELTON, AR; et al. CHANGES IN TYROSINE-PHOSPHORYLATED P190 AND ITS ASSOCIATION WITH P120 TYPE-I AND P100 TYPE-II RASGAPS DURING MYELOMONOCYTIC DIFFERENTIATION OF HUMAN LEUKEMIC-CELLS. CELL GROWTH & DIFFERENTIATION 6:139-148(1995).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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