Anti-ARHGAP25 monoclonal antibody (DCABH-610)

Mouse anti-Human ARHGAP25 monoclonal antibody for WB, ICC/IF Datasheet

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Host Species
Antibody Isotype
Species Reactivity
Recombinant full length protein of Human ARHGAP25 (NP_055697), produced in HEK293T cell.


Application Notes
WB: 1/2000; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.


Alternative Names
ARHGAP25; Rho GTPase activating protein 25; rho GTPase-activating protein 25; KIAA0053; rho-type GTPase-activating protein 25; KAIA0053
Entrez Gene ID
UniProt ID

Product Background

Gene summary
ARHGAP25 (Rho GTPase Activating Protein 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SRGAP3. ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).
Antigen Description
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. The function about ARHGAP25 antigen include GTPase activator activity.
Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by Rho GTPases, organism-specific biosystem.


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Gohla, A; Harhammer, R; et al. The G-protein G(13) but not G(12) mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. JOURNAL OF BIOLOGICAL CHEMISTRY 273:4653-4659(1998).
Rondas, D; Tomas, A; et al. Novel Mechanistic Link between Focal Adhesion Remodeling and Glucose-stimulated Insulin Secretion. JOURNAL OF BIOLOGICAL CHEMISTRY 287:2423-2436(2012).

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