Mouse anti-Human ARHGAP25 monoclonal antibody for WB, ICC/IF
WB: 1/2000; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
ARHGAP25 (Rho GTPase Activating Protein 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SRGAP3. ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. The function about ARHGAP25 antigen include GTPase activator activity.
Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by Rho GTPases, organism-specific biosystem.
MATUOKA, K; SHIBASAKI, F; et al. ASH/GRB-2, A SH2/SH3-CONTAINING PROTEIN, COUPLES TO SIGNALING FOR MITOGENESIS AND CYTOSKELETAL REORGANIZATION BY EGF AND PDGF. EMBO JOURNAL 12:3467-3473(1993).
Gohla, A; Harhammer, R; et al. The G-protein G(13) but not G(12) mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. JOURNAL OF BIOLOGICAL CHEMISTRY 273:4653-4659(1998).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.