Anti-ARHGAP18 PAb (DPABH-23843)

Rabbit anti-Human ARHGAP18 polyclonal antibody for ICC/IF, WB, ICC, IHC-FoFr Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A 15 amino acid synthetic peptide near the C terminus of Human ARHGAP18 (NP_277050).
Conjugate
Unconjugated

Target


Alternative Names
ARHGAP18; Rho GTPase activating protein 18; SENEX; MacGAP; bA307O14.2; rho GTPase-activating protein 18
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ARHGAP18 (Rho GTPase Activating Protein 18) is a Protein Coding gene. Diseases associated with ARHGAP18 include penicilliosis and non-syndromic x-linked intellectual disability. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A. ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al. , 2009 [PubMed 19065146]).
Antigen Description
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). The function about ARHGAP18 antigen include GTPase activator activity.
Pathway
Rho GTPase cycle; Signaling by Rho GTPases.

Citations


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References


Maeda, M; Hasegawa, H; et al. ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility. MOLECULAR BIOLOGY OF THE CELL 22:3840-3852(2011).
Katoh, M; Katoh, M; et al. Characterization of human ARHGAP10 gene in silico. INTERNATIONAL JOURNAL OF ONCOLOGY 25:1201-1206(2004).

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