Anti-ARHGAP12 monoclonal antibody (DCABH-10587) Made to order

Rabbit anti-Human ARHGAP12 monoclonal antibody for WB, ELISA

View other ARHGAP12 antibodies


Host Species
Antibody Isotype
Species Reactivity
A synthetic peptide of human ARHGAP12 is used for rabbit immunization.


Alternative Names
ARHGAP12; Rho GTPase activating protein 12; rho GTPase-activating protein 12; FLJ10971; FLJ20737; FLJ21785
Entrez Gene ID
UniProt ID

Product Background

Gene summary
ARHGAP12 (Rho GTPase Activating Protein 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP9. This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Antigen Description
RHO GTPases (see ARHA, MIM 165390) that participate in a wide variety of cellular processes are active in their GTP-bound form and inactive in their GDP-bound form. The hydrolysis of GTP and the inactivation of these GTPases are regulated by GTPase-activating proteins (GAPs), such as ARHGAP12 (Zhang et al. , 2002 [PubMed 11854031]). GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. The function about ARHGAP12 antigen include GTPase activator activity.
Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by Rho GTPases, organism-specific biosystem.


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Matsuda, M; Kobayashi, Y; et al. Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning. EXPERIMENTAL CELL RESEARCH 314:939-949(2008).

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