Anti-ARFGAP3 monoclonal antibody (DCABH-10582) Made to order

Rabbit anti-Human ARFGAP3 monoclonal antibody for WB, ELISA

View other ARFGAP3 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ARFGAP3 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ARFGAP3; ADP-ribosylation factor GTPase activating protein 3; ADP ribosylation factor GTPase activating protein 1 , ARFGAP1; ADP-ribosylation factor GTPase-activating protein 3; ARF GAP 3; ADP-ribosylation factor GTPase activating protein 1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ARFGAP3 (ADP Ribosylation Factor GTPase Activating Protein 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Unfolded Protein Response (UPR). GO annotations related to this gene include GTPase activator activity and protein transporter activity. An important paralog of this gene is ARFGAP2. The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.
Antigen Description
The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene. 0The function about ARFGAP3 antigen include ARF GTPase activator activity; metal ion binding; protein transporter activity; zinc ion binding.
Pathway
Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem.

Citations


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References


THURSTON, AW; RHEE, SG; et al. ROLE OF GUANINE-NUCLEOTIDE-BINDING PROTEIN AND TYROSINE KINASE IN PLATELET-ACTIVATING-FACTOR ACTIVATION OF PHOSPHOLIPASE-C IN A431 CELLS - PROPOSAL FOR DUAL MECHANISMS. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 266:1106-1112(1993).
CAVENAGH, MM; BREINER, M; et al. ADP-RIBOSYLATION FACTOR (ARF)-LIKE-3, A NEW MEMBER OF THE ARF FAMILY OF GTP-BINDING PROTEINS CLONED FROM HUMAN AND RAT-TISSUES. JOURNAL OF BIOLOGICAL CHEMISTRY 269:18937-18942(1994).

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