Specifications
Immunogen
CENTD2 (AAH56401, 101 a.a. ~ 200 a.a) partial recombinant protein with GST tag. The sequence is DFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRKLQELSIQGDSEN QVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTL
Target
Alternative Names
ARAP1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1; CENTD2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; cnt-d2; centaurin-delta-2; centaurin, delta 2; ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology
Product Background
Antigen Description
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Pathway
Endocytosis; Regulation of RhoA activity; Signal Transduction.
Citations
Publication ()
Have you cited DPAB-DC465 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
