Anti-AR monoclonal antibody, clone BO2-26

Besides aspect ratio AR and excitation wavelength lambda, material composition is also key parameter determining figure of merit (FOM) of individual AuxAg1-x (x = 0, 0.2, 0.3, 0.5, 0.7, 0.8,1.0) alloy nanobars. In this paper, the corresponding x dependent refractive-index sensitivity factor (S) and FOM responses were numerically investigated as functions of AR and lambda by discrete dipole approximation. It demonstrates that S increases nonlinearly/linearly with lambda(LSPR)/AR for all x concerned while FOM achieves x dependent optimum at optimized lambda(LSPR) and AR. With x decreasing, S, FOM and optimal FOM are revealed to increase. The obtained S and FOM responses are analytically explained well by alloy dielectric response under dipolar LSPR condition. The surrounding medium effect on S and FOM response of optimized AuxAg1-x nanobar is discussed as well. The present work provides significant guideline for future Au/Ag based applications in plasmonic sensing and detection. (C) 2020 Elsevier B.V. All rights reserved.

Biomaterial-associated infections caused by pathogenic bacteria have become an urgent threat to public health. Efficient bactericidal strategies that can inactivate bacteria without triggering antimicrobial resistance (AR) are highly desired. Herein, we present a synergistic antibacterial membrane with superhydrophobic and photodynamic bactericidal properties via a facile non-solvent induced phase separation process (NIPS). Benefiting from the excellent liquid-repellence, the synergistic antibacterial hybrid membrane resists most of bacterial adhesion at the initial stage. Subsequently, few of adhered bacteria can be easily eliminated by photodynamical therapy (PDT), in which the bactericidal activity is mediated by cytotoxic reactive oxygen species (ROS) under the visible light illumination, avoiding the risk of AR. This synergistic membrane exhibits highly effective antibacterial performances, as demonstrated by the total kill against Gram-positive S. aureus, and Gram-negative E. coli and P. aeruginosa. Moreover, the membranes also display essential non-fouling performances, as testified by both whole blood adhesion as well as self-cleaning test. Due to its simplification and high-efficiency, this type of membrane may find potential applications as an antibacterial platform for bacterial infection-resistant areas.