Anti-AQP1 monoclonal antibody (CABT-52798MA)

Mouse anti-AQP1 monoclonal antibody for IHC-Fr; ELISA; IHC-P; WB


Host Species
Antibody Isotype
Species Reactivity
Human, Mouse, Rabbit, Rat, Zebrafish
Synthetic peptide corresponding to amino acids 249-269 of aquaporin 1.


Application Notes
ELISA: 1/1,000 - 1/20,000; Western Blot: 1/1,000 - 1/5,000; Immunohistology - Frozen: 1/500 - 1/1,000; Immunohistology - Paraffin: 1/500 - 1/1,000;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.


Alternative Names
AQP1; aquaporin 1 (Colton blood group); CO; CHIP28; AQP-CHIP; aquaporin-1
Entrez Gene ID
UniProt ID

Product Background

Aquaporin-mediated transport; Bile secretion; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide; Metabolism; O2/CO2 exchange in erythrocytes; Passive transport by Aquaporins; Proximal tubule bicarbonate reclamation;


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Custom Antibody Labeling

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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Hypoxia-induced up-regulation of Aquaporin-1 in Rat Schwann cells via the MAPK pathway


Authors: Meng, Wei; Hu, Hao; Jie, Xiang; Gao, Yak; Zhu, Lie; Zhang, Ying; Zhao, Yaozh; Wang, Hui; Jiang, Hua

Background: Aquaporin-1 (AQP1) is a glycoprotein that mediates osmotic water transport. Its expression has been found to be correlated with the swelling of Schwann cells. Hypoxia has been reported to play an important role in inducing the expression of AQP1 during Schwann cell swelling. However, the mechanism that regulates AQP1 expression in Schwann cells remains obscure. Methods: The expression and regulation of AQP1 in Rat Schwann cells was investigated using a tris-gas incubator to build a hypoxia model. Results: The expression of AQP1 was up-regulated upon the induction of hypoxia in cells. Hypoxia also induced the phosphorylation of ERK/p38/JNK MAPK. Specific inhibitors of ERK and p38 MAPK blocked these effects of hypoxia on the expression of AQP1. Conclusion: These findings suggested that AQP1 could be up-regulated in a time-dependent manner by hypoxia at the cellular level and that the regulation of AQP1 in Schwann cells was dependent on ERK and p38 MAPK.

Expressions of aquaporin family in human luteinized granulosa cells and their correlations with IVF outcomes


Authors: Lee, Hee Jun; Jee, Byung Chul; Kim, Seul Ki; Kim, Hoon; Lee, Jung Ryeol; Suh, Chang Suk; Kim, Seok Hyun

STUDY QUESTION: Are mRNAs for specific aquaporins (AQPs) expressed inhuman luteinized granulosa cells (GCs) and are their expression levels correlated with in vitro fertilization (IVF) outcomes? SUMMARY ANSWER: The mRNAs of AQP1-7, 9, 11, and 12 were expressed in human luteinized GCs; the level of AQP1 mRNA was negatively associated with retrieved oocyte number and the level of AQP7 mRNA was positively associated with fertilization rate. WHAT IS KNOWN ALREADY: mRNAs of AQP1-4 and AQP9 have been detected in human GCs. STUDY DESIGN, SIZE, DURATION: Prospective observational study involving 111 women undergoing a stimulated IVF cycle. PARTICIPANTS/MATERIALS, SETTING, METHODS: In a preliminary experiment on 27 women, the mRNA expression of AQP0-12 in GCs was explored by RT-PCR. In the main experiment, luteinized GCs were obtained from 111 women at the time of oocyte retrieval of whom 102 had an embryo replacement. Real-time quantitative RT-PCR (qRT-PCR) was performed to quantify the mRNA level of AQP1-7, 9, 11, and 12. The mRNA for luteinizing hormone receptor (LHR) and steroidogenic acute regulatory protein (StAR) were also quantified by qRT-PCR. MAIN RESULTS AND THE ROLE OF CHANCE: mRNAs for AQP0, 8 and 10 were not detected in the preliminary experiment. In samples from 111 women, retrieved oocyte number was negatively associated with the mRNA levels of AQP1, 4, 6, and 11 and LHR (r = -0.311, r = -0.233, r = -0.203, r = -0.194, and r = -0.202, respectively, P < 0.05 for each), however, after adjustment for woman's age and serum anti-Mullerian hormone (AMH) levels, only correlation with AQP1 was found (r = -0.299, P < 0.05). BMI was negatively associated (after adjustment for age) with the mRNA level of AQP7 (r = -0.259, P < 0.05). Fertilization rate was positively associated with the mRNA level of AQP7 (r = 0.269, P < 0.05). The number or quality of embryos or clinical pregnancy was not associated with the mRNA levels of any of ten AQP subtypes. The mRNA levels for the ten AQP subtypes were correlated positively with LHR expression but negatively with StAR expression. Amongst high responders (oocyte number >= 14), the mRNA levels of AQP11 (1.4 +/- 0.7 versus 1.7 +/- 0.6) and LHR (1.3 +/- 0.7 versus 1.7 +/- 0.7) were significantly lower in the group with PCOS than in the non-PCOS group. LIMITATIONS, REASONS FOR CAUTION: A relative small number of subjects in PCOS group is the main limitation of our study. P-values were not corrected for multiple comparisons. WIDER IMPLICATION OF THE FINDINGS: AQP1 may be one of the factors that modulate individual ovarian response to exogenous gonadotrophin. The mRNA level of AQP7 was positively associated with fertilization rate, which is a surrogate marker of oocyte competence, thus expression of AQP7 could be a marker for adequate folliculogenesis and healthy oocytes.

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