Anti-ANTXR2 monoclonal antibody (DCABH-10525) Made to order

Rabbit anti-Human ANTXR2 monoclonal antibody for ICC/IF, IHC-P, WB

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Rat, Human
Immunogen
A synthetic peptide of human ANTXR2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ANTXR2; anthrax toxin receptor 2; capillary morphogenesis protein 2; CMG 2; CMG2; FLJ31074
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ANTXR2 (Anthrax Toxin Receptor 2) is a Protein Coding gene. Diseases associated with ANTXR2 include hyaline fibromatosis syndrome and hyalinosis, inherited systemic. Among its related pathways are Infectious disease and Cellular roles of Anthrax toxin. GO annotations related to this gene include receptor activity. An important paralog of this gene is ANTXR1. This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. Hyaline fibromatosis syndrome (HFS) [MIM:228600]: An autosomal recessive syndrome characterized by abnormal growth of hyalinized fibrous tissue usually affecting subcutaneous regions on the scalp, ears, neck, face, hands, and feet. The lesions appear as pearly papules or fleshy nodules. Additional features include gingival hypertrophy, progressive joint contractures resulting in severe limitation of mobility, osteopenia, and osteoporosis. Disease severity is variable. Some individuals manifest symptoms in infancy and have additional visceral or systemic involvement. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to early death. Surviving children may suffer from severely reduced mobility due to joint contractures. Other patients have later onset of a milder disorder affecting only the face and digits. Note=The disease is caused by mutations affecting the gene represented in this entry. Anthrax toxin receptor 2 is a protein that in humans is encoded by the ANTXR2 gene. 0The function about ANTXR2 antigen include metal ion binding; protein binding; receptor activity.
Pathway
Cellular roles of Anthrax toxin, organism-specific biosystem.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Mabry, R; Brasky, K; et al. Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays. CLINICAL AND VACCINE IMMUNOLOGY 13:671-677(2006).
Sharma, S; Thomas, D; et al. Efficient Neutralization of Antibody-Resistant Forms of Anthrax Toxin by a Soluble Receptor Decoy Inhibitor. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 53:1210-1212(2009).

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