Anti-ALPP monoclonal antibody, clone FQS7252

Antibody Isotype

IgG

Clone

FQS7252

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region within the extracellular domain of Human Placental alkaline phosphatase (PLAP)

Conjugate

Application Notes

WB: 1/10000 - 1/50000; IHC-P: 1/250 - 1/500; ICC: 1/100 - 1/250;

Alternative Names

ALPP; alkaline phosphatase, placental; alkaline phosphatase, placental (Regan isozyme); alkaline phosphatase, placental type; Regan isozyme; PLAP-1; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase R

Entrez Gene ID

UniProt ID

Antigen Description

here are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 5 while the tissue non-specific form is located on chme 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized

Pathway

Folate biosynthesis, organism-specific biosystem; Folate biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem;