Anti-ALG3 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human ALG3 is used for rabbit immunization.

Conjugate

Alternative Names

ALG3; ALG3, alpha-1,3- mannosyltransferase; CDG1D; CDGS4; Not56; NOT56L; D16Ertd36e; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Not56-like protein; asparagine-linked glycosylation protein 3 homolog; dol-P-Man dependent alpha(1-3)-mann

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene.

Pathway

Asparagine N-linked glycosylation; Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Metabolism of proteins; N-Glycan biosynthesis; N-Glycan biosynthesis; N-glycan precursor biosynthesis;Post-translational protein modification; dolichyl-diphosphooligosaccharide biosynthesis;