This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene.
Pathway
Asparagine N-linked glycosylation; Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Metabolism of proteins; N-Glycan biosynthesis; N-Glycan biosynthesis; N-glycan precursor biosynthesis;Post-translational protein modification; dolichyl-diphosphooligosaccharide biosynthesis;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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VEROSTEK, MF; TRIMBLE, RB; et al. MANNOSYLTRANSFERASE ACTIVITIES IN MEMBRANES FROM VARIOUS YEAST STRAINS. GLYCOBIOLOGY 5:671-681(1995).
KurzikDumke, U; Kaymer, M; et al. Gene within gene configuration and expression of the Drosophila melanogaster genes lethal(2) neighbour of tid [l(2)not] and lethal(2) relative of tid [l(2) rot]. GENE 200:45-58(1997).
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COA
Certificate of Analysis