General Notes
This product (Catalog No. DPABH-24924) is a rabbit-derived polyclonal antibody raised against human ALDH1A1, targeting the amino acid region 153–501 of the protein. This antibody exhibits cross-reactivity with Human ALDH1A1 from mouse and rat. It has been affinity purified by Protein A. ALDH1A1(Aldehyde dehydrogenase family 1 member A1 ), also named as ALDC, ALDH1 and PUMB1, belongs to the aldehyde dehydrogenase family. The ALDH1A1 gene encodes a liver cytosolic isoform of acetaldehyde dehydrogenase, an enzyme involved in the major pathway of alcohol metabolism after alcohol dehydrogenase. ALDH1A1 plays a critical role in protection against oxidative stress-induced cytotoxicity in lens epithelial cells(PMID:19296407). And it is important for multiple biological activities including drug resistance, cell differentiation, and oxidative stress response(PMID:19025616). As a novel cancer stem cell marker, ALDH1A1 can be used for tumors whose corresponding normal tissues express ALDH1 in relatively restricted or limited levels such as breast, lung, ovarian or colon cancer(PMID: 20422001).
DPABH-24924 is suitable for use in Western blot (WB) (1:5,000–1:50,000), IHC (1:50–1:500), IF-P (1:50–1:500), IF/ICC (1:200–1:800), flow cytometry (FC) (0.20 μg per 10^6 cells in a 100 μl suspension) applications.
DPABH-24924 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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