Anti-Albumin monoclonal antibody, clone FQS23891(C)

Introduction: Inflammation of gall bladder is a frequently seen gall bladder disease and the determination of the severity of disease requires many parameters. Wall thickness of the gall bladder is one of the first sign of the local inflammation. CRP and albumin are remarkable acute phase reactants to help to understand whether further investigation or treatment is necessary. The aim of the present study was to assess the association between wall thickness of the gall bladder and CRP/Alb ratio in the patients referring due to right upper quadrant pain. Methods: The patients who have referred the department of emergency medicine due to right abdominal quadrant pain and has both hepatobiliary ultrasound (US), computed tomography (CT) were enrolled into the study. Age, gender, referral complaint examination findings (Murphy's sign, right upper quadrant pain) and laboratory analyses (CRP, Alb) of the patients were recorded retrospectively from the hospital record system. Ultrasound and CT findings were existence of biliary stone, pericholecystic fluid and increase in wall thickness of gall bladder (> 3mm). Significance was accepted as p<0.05. Results: The present study was performed with 129 cases including 54 (41.9%) males and 75 (58.1%) females. The age range of the participants was between 18 and 89 and the age average was 48.90 +/- 17.62 years .CRP/Alb ratios of the patients with gall bladder wall thickness over 3 mm in CT scan were significantly higher than those with gall bladder wall thickness of 3 mm and thinner (p=0.001; p<0,01).There is a statistically significant difference detected in CRP/Alb ratios of the patients with gall bladder wall thickness over 3 mm by US (p=0.003; p<0.01). Discussion: Some laboratory parameters may help the physicians when imaging methods such as US and CT do not exist or there are limitations for imaging. Our study showed that elevation of CRP/Alb is significantly associated with increase in wall thickness of the gall bladder. We believe that these parameters may be functional in the algorithms of diagnosis and treatment.

Objective: Diabetic nephropathy is a serious threat to human health, and its incidence is on the rise. End-stage diabetic nephropathy (ESDN) requires extra investigation due to its complexity and severity, as well as serious concurrent diseases. Our objective was to compare the efficacy of hemodialysis (HD) and peritoneal dialysis (PD) in the treatment of ESDN. Methods: Clinical data of 84 patients with ESDN admitted to our hospital from June 2016 to June 2018 were retrospectively analyzed. The patients were divided into an HD group that received hemodialysis and a PD group that received peritoneal dialysis. Their general conditions, biochemical indicators, residual renal function and incidence of complications were recorded and compared between the two groups. Results: (1) No significant difference in diastolic blood pressure, systolic blood pressure, body weight, or urine output was detected between the two groups at the beginning of dialysis (P>0.05). (2) Compared to the PD group, the HD group had significantly lower total cholesterol (TC) and triglyceride (TG) (P<0.05), and significantly higher total protein (TP) and albumin (ALB) after treatment (P<0.05). (3) The two groups also showed significant difference in residual renal function after treatment (P<0.05). (4) The HD group had significantly higher systolic pressure than the PD group after treatment (P<0.05). And more cases of infection were observed in the PD group than the HD group (P<0.05). Conclusion: Both HD and PD are used for treatment of ESDN, and can achieve similar calcium and phosphorus control. Compared to HD, PD has less adverse effect on hemodynamics and better preserves residual renal function, but is more likely to cause malnutrition and disorders of lipid metabolism. Therefore, choice of dialysis method should be based on specific conditions of each patient.