Anti-AKT3 (aa 100-189) polyclonal antibody

Species Reactivity

Human

Immunogen

AKT3 (AAD29089, 100 a.a. ~ 189 a.a) partial recombinant protein with GST tag. The sequence is EAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTF GKVILVREKASGKYYAMKILKKEVIIAKDE

Conjugate

Alternative Names

AKT3; v-akt murine thymoma viral oncogene homolog 3; MPPH; PKBG; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma; RAC-gamma serine/threonine-protein kinase; PKB gamma; RAC-gamma serine/threonine protein kinase; v-akt murine thymoma viral oncogene homolog

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.

Pathway

AKT phosphorylates targets in the cytosol; AKT-mediated inactivation of FOXO1A; AMPK signaling pathway; Activation of BH3-only proteins