Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide: CSPTSQIDNIGEEEMDAS, corresponding to amino acids 119-136 of Human AKT3. This sequence is identical in human, mouse and rat.
Applications
Application Notes
WB: 1 - 2 μg/ml; ICC/IF: 1 - 5 μg/ml; Flow Cyt: 1-2μg/106 cells;
Target
Alternative Names
AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); RAC-gamma serine/threonine-protein kinase; PKBG; PRKBG; RAC gamma; PKB gamma; RAC-gamma serine/threonine protein kinase; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma; DKFZp434N025
Product Background
Antigen Description
IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
Pathway
AKT phosphorylates targets in the cytosol, organism-specific biosystem; AKT phosphorylates targets in the nucleus, organism-specific biosystem; AKT-mediated inactivation of FOXO1A, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem;
Citations
Publication ()
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COA
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