Anti-AKAP12 (aa 1675-1782) polyclonal antibody

Species Reactivity

Human

Immunogen

AKAP12 (NP_005091, 1675 a.a. ~ 1782 a.a) partial recombinant protein with GST tag. The sequence is VPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPK QKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES

Conjugate

Alternative Names

AKAP12; A kinase (PRKA) anchor protein 12; SSeCKS; AKAP250; A-kinase anchor protein 12; AKAP 250; kinase scaffold protein gravin; A-kinase anchor protein, 250kDa; Src-Suppressed C Kinase Substrate; myasthenia gravis autoantigen gravin;

Entrez Gene ID

UniProt ID

Antigen Description

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Pathway

G Protein Signaling Pathways;