Anti-AES (C-terminal) polyclonal antibody

This paper analyses the performance of a multi-attribute auction for securing agri-environmental outcomes and cost-effective agri-environmental payments (AEPs). We set up a discriminatory price auction model in which farmers make an offer based on two attributes (i.e. the AEP and a proxy of environmental outcome). We provide a numerical simulation for a hypothetical agri-environmental scheme (AES) in Italy using FADN data 2011 for the Emilia-Romagna region (E-R). In three implementation scenarios, we compare the Budgetary cost-effectiveness (BCE), the Economic cost-effectiveness (ECE) and Information rent (IR) of the auction with that of two alternative policy instruments (i.e. uniform payment and marginal flat rate payment). Due to the heterogeneity in bidders' opportunity costs, the auction is more cost-effective than a uniform payment in delivering the target outcome. The performance indicators are sensitive to the farmers' expectations about the bid caps, revealing the opportunity of using both competition effect and information leverage associated with the implementation mechanism to increase the auction outcome when the budget is limited.

Background and Purpose: We determined the rates and predictors of acute kidney injury (AKI) and renal adverse events (AEs), and effects of AKI and renal AEs on death or disability in patients with intracerebral hemorrhage. Methods: We analyzed data from a multicenter trial which randomized 1000 intracerebral hemorrhage patients with initial systolic blood pressure >= 180 mm Hg to intensive (goal 110-139 mm Hg) over standard (goal 140-179 mm Hg) systolic blood pressure reduction within 4.5 hours of symptom onset. AKI was identified by serial assessment of daily serum creatinine for 3 days post randomization. R Results: AKI and renal AEs were observed in 149 patients (14.9%) and 65 patients (6.5%) among 1000 patients, respectively. In multivariate analysis, the higher baseline serum creatinine (>= 110 mu mol/L) was associated with AKI (odds ratio 2.4 [95% CI, 1.2-4.5]) and renal AEs (odds ratio 3.1 [95% CI, 1.2-8.1]). Higher area under the curve for intravenous nicardipine dose was associated with AKI (odds ratio 1.003 [95% CI, 1.001-1.005]) and renal AEs (odds ratio 1.003 [95% CI, 1.001-1.006]). There was a higher risk to death (relative risk 2.6 [95% CI, 1.6-4.2]) and death or disability (relative risk 1.5 [95% CI, 1.3-1.8]) at 90 days in patients with AKI but not in those with renal AEs. Conclusions: Intracerebral hemorrhage patients with higher baseline serum creatinine and those receiving higher doses of nicardipine were at higher risk for AKI and renal AEs. Occurrence of AKI was associated higher rates of death or disability at 3 months. REGISTRATION: URL: https://clinicaltrials.gov. Unique identifier: NCT01176565.