Anti-ADAMTS14 monoclonal antibody (DCABH-10411) Made to order

Rabbit anti-Human ADAMTS14 monoclonal antibody for WB, ELISA

View other ADAMTS14 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ADAMTS14 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ADAMTS14; ADAM metallopeptidase with thrombospondin type 1 motif, 14; a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14; A disintegrin and metalloproteinase with thrombospondin motifs 14; ADAM-TS14; ADAMTS-14
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ADAMTS14 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 14) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and O-linked glycosylation. GO annotations related to this gene include peptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS20. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined.
Antigen Description
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined. Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. The function about ADAMTS14 antigen include metal ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Sakamoto, N; Oue, N; et al. Serial analysis of gene expression of esophageal squamous cell carcinoma: ADAMTS16 is upregulated in esophageal squamous cell carcinoma. CANCER SCIENCE 101:1038-1044(2010).
Tota, G; Coccaro, N; et al. ADAMTS2 gene dysregulation in T/myeloid mixed phenotype acute leukemia. BMC CANCER 14:-(2014).

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