Specifications
Immunogen
Freshly ejaculated human sperms (washed in PBS and extracted in 3% acetic acid, 10% glycerol, 30 mM benzaminidine. The acid extract was dialyzed against 0.2% acetic acid and subsequently used for immunization).
Target
Alternative Names
ACRV1; acrosomal vesicle protein 1; acrosomal protein SP-10; D11S4365; SP 10; SPACA2; sperm protein 10; SP-10;
Product Background
Antigen Description
This gene encodes a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain. The protein is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in MYH9 are the cause of non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness.
Citations
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Margalit, M; Yogev, L; et al. Involvement of the prostate and testis expression (PATE)-like proteins in spermoocyte interaction. HUMAN REPRODUCTION 27:1238-1248(2012).
Osuru, HP; Monroe, JE; et al. The Acrosomal Protein SP-10 (Acrv1) is an Ideal Marker for Staging of the Cycle of Seminiferous Epithelium in the Mouse. MOLECULAR REPRODUCTION AND DEVELOPMENT 81:896-907(2014).
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Certificate of Analysis
