General Notes
This product (Catalog No. DPABH-24081) is a rabbit-derived polyclonal antibody raised against human ACADL, targeting the amino acid region 214–430 of the protein. This antibody exhibits cross-reactivity with Human ACADL from mouse and rat. It has been affinity purified by Protein A. ACADL is a human gene that encodes the mitochondrial enzyme acyl-CoA dehydrogenase, long chain (LCAD), which catalyzes the initial dehydrogenation step in the beta-oxidation of long-chain fatty acids (C12–C18) within the mitochondrial matrix. This enzyme is essential for fatty acid metabolism, facilitating energy production by breaking down lipids into acetyl-CoA for the citric acid cycle and oxidative phosphorylation. Located on chromosome 2q31.1, ACADL spans approximately 38 kb and consists of 11 exons, producing a 48 kDa protein that forms a homotetramer and requires flavin adenine dinucleotide (FAD) as a cofactor. Mutations in ACADL can lead to deficiencies in long-chain acyl-CoA dehydrogenase activity, potentially contributing to metabolic disorders such as acyl-CoA dehydrogenase deficiencies, though overt clinical phenotypes are rare compared to related enzymes like very long-chain acyl-CoA dehydrogenase (ACADVL).
DPABH-24081 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-24081 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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