Anti-ABHD5 monoclonal antibody (DCABH-809)

Mouse anti-Human ABHD5 monoclonal antibody for WB, IHC-P Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
2G4
Species Reactivity
Human
Immunogen
Recombinant full length protein (Human)
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/1000; IHC-P: 5 μg/ml;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ABHD5; abhydrolase domain containing 5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; CGI 58; NCIE2; lipid droplet-binding protein CGI-58
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ABHD5 (Abhydrolase Domain Containing 5) is a Protein Coding gene. Diseases associated with ABHD5 include chanarin-dorfman syndrome and neutral lipid storage disease. Among its related pathways are Lipoprotein metabolism and Metabolism. GO annotations related to this gene include peptidase activity and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is ABHD4. The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation.
Antigen Description
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Chanarin-Dorfman syndrome (CDS) [MIM:275630]: An autosomal recessive inborn error of lipid metabolism with multisystemic accumulation of triglycerides although plasma concentrations are normal. Clinical characteristics are congenital generalized ichthyosis, vacuolated leukocytes, hepatomegaly, myopathy, cataracts, neurosensory hearing loss and developmental delay. The disorder presents at birth with generalized, fine, white scaling of the skin and a variable degree of erythema resembling non-bullous congenital ichthyosiform erythroderma. Note=The disease is caused by mutations affecting the gene represented in this entry. 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 is an enzyme that in humans is encoded by the ABHD5 gene. The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. The function about ABHD5 antigen include 1-acylglycerol-3-phosphate O-acyltransferase activity; lysophosphatidic acid acyltransferase activity; transferase activity, transferring acyl groups; NOT triglyceride lipase activity.
Pathway
CDP-diacylglycerol biosynthesis I, organism-specific biosystem; Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; phosphatidylglycerol biosynthesis II (non-plastidic), organism-specific biosystem; triacylglycerol biosynthesis, organism-specific biosystem.

Citations


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References


Demiralp, DO; Haznedaroglu, IC; et al. Functional proteomic analysis of Ankaferd (R) Blood Stopper. TURKISH JOURNAL OF HEMATOLOGY 27:70-77(2010).
Wiedl, T; Arni, S; et al. Activity-based proteomics: Identification of ABHD11 and ESD activities as potential biomarkers for human lung adenocarcinoma. JOURNAL OF PROTEOMICS 74:1884-1894(2011).

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