Anti-ABCB10 polyclonal antibody (DPAB-DC1107)

Specifications


Host Species
Goat
Species Reactivity
Human
Immunogen
A synthetic peptide corresponding to human ABCB10. The sequence is C-KPNGIYRKLMNKQ
Conjugate
Unconjugated

Applications


Application Notes
ELISA: 1:64000. & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ABCB10; ATP-binding cassette, sub-family B (MDR/TAP), member 10; M-ABC2; MTABC2; EST20237; ATP-binding cassette sub-family B member 10, mitochondrial
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ABCB10 (ATP Binding Cassette Subfamily B Member 10) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and ABC-family proteins mediated transport. GO annotations related to this gene include protein homodimerization activity and ATPase activity. An important paralog of this gene is TAP1. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown.
Antigen Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. May mediate critical mitochondrial transport functions related to heme biosynthesis. The function about ABCB10 antigen include ATP binding; ATPase activity, coupled to transmembrane movement of substances; protein homodimerization activity; transporter activity.
Pathway
ABC transporters; ABC-family proteins mediated transport; Transmembrane transport of small molecules.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Kang, YK; et al. Expression of Multidrug Resistance Protein 1 in Human Hepatocellular Carcinoma. KOREAN JOURNAL OF PATHOLOGY 45:281-289(2011).
Wong, LJC; Dimmock, D; et al. Utility of oligonucleotide array-based comparative genomic hybridization for detection of target gene deletions. CLINICAL CHEMISTRY 54:1141-1148(2008).

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