Anti-3-DG-imidazolone monoclonal antibody (DMAB12600)
Mouse anti-3-DG-imidazolone monoclonal antibody for IHC
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Human, Mouse, Rat
3-DG-imidazolone conjugated with HSA.
Immunohistochemistry (7 μg/mL) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
3-DG-imidazolone; Anti-3-DG-imidazolone MAb; Mouse Anti-3-DG-imidazolone Monoclonal Antibody
It has been shown that Advanced Glycation End products (AGEs) have been involved in chronic disease with aging, such as diabetes or brain disease. So far, several AGEs structure has been identified, and these studies shed light on the important role of the growth of the disease. Imidazolone is one of AGEs structure, and has been shown that there are two pathways to generate. One is through 3-deoxyglucosone (3-DG) and another is through methlglyoxal. But it is not clear which pathway is dominant in each chronic disease.
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Jono, T; Nagai, R; et al. N-epsilon-(carboxymethyl)lysine and 3-DG-imidazolone are major AGE structures in protein modification by 3-deoxyglucosone. JOURNAL OF BIOCHEMISTRY 136:351-358(2004).
Jono, T; Nagai, R; et al. Detection of 3-deoxyglucosone-derived AGE structures in vitro. MAILLARD REACTION IN FOOD CHEMISTRY AND MEDICAL SCIENCE: UPDATE FOR THE POSTGENOMIC ERA 1245:239-242(2002).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.