Anti-25 OH Vitamin D3 monoclonal antibody (DMAB2913)

Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
L35235N
Species Reactivity
N/A
Immunogen
25 (OH) D3 3-Hemisuccinat-BSA.
Conjugate
Unconjugated

Applications


Application Notes
Suitable for use in ELISA (1:15,000-50,000). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
Calcitriol; 1, 25 (OH)2 VITAMIN D3; 1,25-dihydroxycholecalciferol; 1,25-dihydroxyvitamin D3; 1,25-(OH)2D3; 1,25(OH)2D

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Low energy irradiation of narrow-range UV-LED prevents osteosarcopenia associated with vitamin D deficiency in senescence-accelerated mouse prone 6

SCIENTIFIC REPORTS

Authors: Makida, Kazuya; Nishida, Yoshihiro; Morita, Daigo; Ochiai, Satoshi; Higuchi, Yoshitoshi; Seki, Taisuke; Ikuta, Kunihiro; Ishiguro, Naoki

Deficiency of vitamin D is an important cause of osteosarcopenia. The purpose of this study is to examine the effects of low energy narrow-range UV-LED on osteosarcopenia in animal models of senescence-accelerated mouse prone 6 (SAMP6). Preliminary experiments specified the minimum irradiance intensity and dose efficacy for vitamin D production (316 nm, 0.16 mW/cm(2), 1,000 J/m(2)). we set a total of 4 groups (n=8 per group); vitamin D-repletion without UV irradiation (Vit.D+UV-), vitamin D-repletion with UV irradiation (Vit.D+UV+), vitamin D-deficiency without UV irradiation, (Vit.D-UV-), and vitamin D-deficiency with UV irradiation (Vit.D-UV+). Serum levels of 25(OH)D at 28 and 36 weeks of age were increased in Vit.D-UV+ group as compared with Vit.D-UV-group. Trabecular bone mineral density on micro-CT was higher in Vit.D-UV+ group than in Vit.D-UV- group at 36 weeks of age. In the histological assay, fewer osteoclasts were observed in Vit.D-UV+ group than in Vit.D-UV- group. Grip strength and muscle mass were higher in Vit.D-UV+ group than in Vit.D-UV- group at 36 weeks of age. Signs of severe damage induced by UV irradiation was not found in skin histology. Low energy narrow-range UV irradiation may improve osteosarcopenia associated with vitamin D deficiency in SAMP6.

Specific cut-off for the 25-OH vitamin D levels to predict the highest Body Mass Index and fat mass: a sex-related analysis in obese patients

MINERVA ENDOCRINOLOGICA

Authors: Barrea, Luigi; Colao, Annamaria; Savastano, Silvia; Muscogiuri, Giovanna

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