Low energy irradiation of narrow-range UV-LED prevents osteosarcopenia associated with vitamin D deficiency in senescence-accelerated mouse prone 6
Authors: Makida, Kazuya; Nishida, Yoshihiro; Morita, Daigo; Ochiai, Satoshi; Higuchi, Yoshitoshi; Seki, Taisuke; Ikuta, Kunihiro; Ishiguro, Naoki
Deficiency of vitamin D is an important cause of osteosarcopenia. The purpose of this study is to examine the effects of low energy narrow-range UV-LED on osteosarcopenia in animal models of senescence-accelerated mouse prone 6 (SAMP6). Preliminary experiments specified the minimum irradiance intensity and dose efficacy for vitamin D production (316 nm, 0.16 mW/cm(2), 1,000 J/m(2)). we set a total of 4 groups (n=8 per group); vitamin D-repletion without UV irradiation (Vit.D+UV-), vitamin D-repletion with UV irradiation (Vit.D+UV+), vitamin D-deficiency without UV irradiation, (Vit.D-UV-), and vitamin D-deficiency with UV irradiation (Vit.D-UV+). Serum levels of 25(OH)D at 28 and 36 weeks of age were increased in Vit.D-UV+ group as compared with Vit.D-UV-group. Trabecular bone mineral density on micro-CT was higher in Vit.D-UV+ group than in Vit.D-UV- group at 36 weeks of age. In the histological assay, fewer osteoclasts were observed in Vit.D-UV+ group than in Vit.D-UV- group. Grip strength and muscle mass were higher in Vit.D-UV+ group than in Vit.D-UV- group at 36 weeks of age. Signs of severe damage induced by UV irradiation was not found in skin histology. Low energy narrow-range UV irradiation may improve osteosarcopenia associated with vitamin D deficiency in SAMP6.
Specific cut-off for the 25-OH vitamin D levels to predict the highest Body Mass Index and fat mass: a sex-related analysis in obese patients
Authors: Barrea, Luigi; Colao, Annamaria; Savastano, Silvia; Muscogiuri, Giovanna