Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidn
Belongs to the peptidase M2 family.
Secreted and Cell membrane.
Preservative: 0.02% Sodium Azide Constituents: 0.1% BSA, PBS, pH 7.2
0.02% Sodium Azide
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Preservative: 0.02% Sodium Azide Constituents: 0.1% BSA, PBS, pH 7.2
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
carboxypeptidase activity; endopeptidase activity; glycoprotein binding; NOT metallopeptidase activity; peptide hormone binding; NOT peptidyl-dipeptidase activity; protein binding; virus receptor activity; virus receptor activity; zinc ion binding;
ACE2; angiotensin I converting enzyme 2; ACEH; angiotensin-converting enzyme 2; peptidyl-dipeptidase A; metalloprotease MPROT15; ACE-related carboxypeptidase; angiotensin-converting enzyme homolog; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2;