Albendazole [HRP]

Product Overview

Albendazole, HRP conjugate

Target

Albendazole

Nature

Synthetic

Tag/Conjugate

HRP

Application Notes

Matched pair antibody available for Albendazole [HRP]: Albendazole antibody (Catalog # HMABPY057)

Format

Concentrate

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

Albendazole, marketed as Albenza (United States), Eskazole, Zentel, Andazol, and Alworm, is a benzimidazole drug used for the treatment of a variety of parasitic worm infestations. It is marketed in the U.S. by Amedra Pharmaceuticals, and by GlaxoSmithKline in international markets. Albendazole was first discovered at the SmithKline Animal Health Laboratories in 1972. It is a broad-spectrum anthelmintic, effective against roundworms, tapeworms, and flukes of domestic animals and humans. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.

Antigen Description

Anthelmintics or anti-helminthics are a class of drugs that are effective against a range of intestinal parasitic worms (helminths). Parasitic helminths must maintain an appropriate feeding site. Nematodes and trematodes must actively ingest and move food through their digestive tracts to maintain an appropriate energy state; these together with reproductive processes require a well defined and developed neuromuscular coordination. Anthelmintic treatment is a multi-targeting system designed to interfere with the integrity of parasite cells. The pharmacologic basis of the treatment for helminths involves the targeting of neuromuscular coordination, or protective mechanisms against host immunity, which lead to starvation, paralysis, and expulsion of the parasite. The benzimidazole class of drugs were introduced in 1961 and interfere with the parasite's ATP pathway on a cellular level. They bind to a specific building block called b-tubulin and prevent its incorporation into certain cellular structures called microtubules, which are essential for energy metabolism.

Keywords

Albendazole