Albendazole Elisa Kit (DEIANJ15)

Regulatory status: For research use only, not for use in diagnostic procedures.

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Size
96T
Sample
meat, feed
Species Reactivity
N/A
Intended Use
Albendazole ELISA Kit is a competitive enzyme immunoassay for the quantitative analysis of Albendazole in meat and feed.
Storage
Store the kit at 2 - 8°C.
Precision
Interplate and intraplate CV typically < 10%
Detection Range
meat 1ppb
feed 2ppb
Sensitivity
0.15 ppb
General Description
Albendazole, also known as albendazolum, is a medication used for the treatment of a variety of parasitic worm infestations. It is useful for giardiasis, trichuriasis, filariasis, neurocysticercosis, hydatid disease, pinworm disease, and ascariasis, among others.
Common side effects include nausea, abdominal pains, and headaches. Potentially serious side effects include bone marrow suppression which usually improves on stopping the medication. Liver inflammation has been reported and those with prior liver problems are at greater risk. It is pregnancy category C in the United States and category D in Australia, meaning it may cause harm if taken by pregnant women. Albendazole is a broad-spectrum antihelminthic agent of the benzimidazole type.

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References


Nanostructured lipid carriers of ivermectin as a novel drug delivery system in hydatidosis

PARASITES & VECTORS

Authors: Ahmadpour, Ehsan; Godrati-Azar, Zahra; Spotin, Adel; Norouzi, Roghayeh; Hamishehkar, Hamed; Nami, Sanam; Heydarian, Peyman; Rajabi, Saba; Mohammadi, Maryam; Perez-Cordon, Gregorio

Background: The larval stage of the tapeworm Echinococcus granulosus is the causative agent of hydatid disease in humans. This zoonotic parasitic infection remains a major health problem in certain areas of the world where is still endemic. In view of the ineffectiveness of some drug treatments, the surgical removal of cysts remains the preferred treatment option together with the administration of albendazole and mebendazole. However, severe side effects of these drugs have been reported which demands developing new scolicidal agents that confer suitable efficacy and fewer side effects during surgery. Methods: To that purpose, in the present work we assessed the effectiveness of ivermectin (IVM), a macrocyclic lactone endectocide that has shown to be an effective nematocidal drug against other important parasitic infections. To overcome the limitations observed in some drug formulations and resistance, we used nano lipid carriers (NLCs) as a targeted and sustained drug delivery system for IVM. We evaluated the in vitro cestocidal and apoptotic effects of NLCs-loaded IVM versus IVM by quantifying the expression of caspase-3 mRNA. Results: We found that after 60 and 120 min of administration, 800 mu g/ml and 400 mu g/ml NLCs-loaded IVM induced 100% mortality, respectively. On the other hand, the 800 mu g/ml of IVM induced 100% mortality rate 150 min after administration. Additionally, we found that NLCs-loaded IVM induced higher mRNA caspase-3 expression suggesting a more potent apoptotic effect on the parasite. Conclusions: These data suggest that NLCs-loaded IVM may be a promising alternative to current treatments although in vivo studies are needed.

Anthelmintic and antimicrobial activity of Indigofera oblongifolia leaf extracts

SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Authors: Dkhil, Mohamed A.; Zreiq, Rafat; Hafiz, Taghreed A.; Mubaraki, Murad A.; Sulaiman, Shadi; Algahtani, Fahad; Abdel-Gaber, Rewaida; Al-Shaebi, Esam M.; Al-Quraishy, Saleh

Due to the endless emergence of drug resistant pathogens, there is a constant need for new therapeutic agents for clinical use. The identification of active components in natural products and determining the efficacy of these active components has become the current focus of pharmacological research. The present study aimed to evaluate the anthelmintic and antimicrobial activities of Indigofera oblongifolia leaf extract (ILE) against the earthworm Allolobophora caliginosa, the gram-positive bacteria (Bacillus cereus, Streptococcus pneumoniae, and Staphylococcus aureus), the gram-negative bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli) and the yeast Candida albicans. Methanolic extract of I. oblongifolia leaf was obtained and the total phenolics and flavonoids in ILE were determined. The anthelmintic study was carried out to determine the time to paralysis and time to death of worms using three doses (100, 200, and 300 mg/mL) of ILE. Also, Kirby-Bauer disk diffusion susceptibility method was used to determine the antimicrobial activity of ILE. The results showed that ILE induces paralysis and death of A. caliginosa at all concentration tested faster than the reference drug, Albendazole. Additionally, ILE exhibited prominent antimicrobial activity against all gram-positive bacteria tested but almost no significant activity against the gram-negative bacteria, except K. pneumoniae. ILE showed close similarity to the spectrum of chloramphenicol and cefoxitin activities. Furthermore, C. albicans was highly susceptible to the leaf extracts. Our results showed that ILE is an effective anthelmintic and antimicrobial agent. (C) 2019 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

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