Human Alanyl-tRNA Synthetase (PL-12) [His], recombinant protein from Baculovirus
Recombinant human Alanyl-tRNA Synthetase (PL-12), his-tagged
SDS-PAGE (purity > 90%); Western blot with i: Polymyositis sera; ii:monoclonal anti-hexa-His-tag antibody.
0.3-0.8 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
2-8°C short term, -20°C long term
Alanyl-tRNA synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 108 kDa protein is an autoantigen recognized by PL-12 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that epitope spreading occurs in the autoimmune PL-12 response such that even antibodies to an isolated alanyl-tRNA molecule can develop
AARS2; alanyl-tRNA synthetase 2, mitochondrial (putative); AARSL,alanyl tRNA synthetase like; alanyl-tRNA synthetase, mitochondrial; alanine tRNA ligase 2; mitochondrial (putative); bA444E17.1; KIAA1270; AARSL; bA444E17.1; Gm89; MT ALARS; MTALARS; AARS 2;