HCV type 1a Active Nonstructural Protein 5 (DAG-P2804)

HCV type 1a Active Nonstructural Protein 5 (aa 2322 - 2423), recombinant protein from E. coli Datasheet

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Product Overview
Active hepatitis c virus Hepatitis C Virus genotype 1a NS5 protein fragment
Nature
Recombinant
Tag/Conjugate
Unconjugated
Cellular Localization
Endoplasmic reticulum membrane
Bio-activity
Active hepatitis c virus Hepatitis C Virus genotype 1a NS5 protein fragment is immunoreactive with sera of HCV-infected individuals.
Purity
> 95 % by SDS-PAGE.This antigen was purified by a proprietary chromatographic technique.
Format
Liquid
Buffer
Preservative: None Constituents: 50mM Tris, 5mM EDTA, pH 8
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Preservative: None Constituents: 50mM Tris, 5mM EDTA, pH 8 This product is an active protein and may elicit a biological response in vivo, handle with
Introduction
Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral protease
Antigen Description
Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha. NS5A is a ~56 kDa pleiotropic protein with key roles in both viral RNA replication and modulation of the physiology of the host cell. It's exact role is not currently known (2008). NS5B (non-structural protein 5B) is an RNA-dependant RNA polymerase responsible for replication of the hepatitis C viral genome, and is currently a principal target for chemotherapeutic inhibition of HCV replication. Hepatitis C virus (HCV) can cause chronic hepatitis, cirrhosis and hepatocellular carcinoma. At present there is no vaccine effective against HCV.
Keywords
HCV 1a NS5; Hepatitis C virus NS5A; Non-structural protein 5A; p56; HCV genotype 1a NS5

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