HCV type 1a Active Nonstructural Protein 5 (aa 2212 - 2313), recombinant protein from E. coli
Active hepatitis c virus Hepatitis C Virus genotype 1a NS5 protein fragment
Endoplasmic reticulum membrane
This protein is immunoreactive with sera of HCV-infected individuals.
> 95 % by SDS-PAGE.This protein was purified by proprietary chromatographic techniques.
Preservative: None Constituents: 50% Glycerol, 0.2% Triton-X, 1.5M Urea, 25mM Tris HCl, pH 8
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze/thaw cycles.
Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral protease
The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha. NS5A is a ~56 kDa pleiotropic protein with key roles in both viral RNA replication and modulation of the physiology of the host cell. It's exact role is not currently known (2008). NS5B (non-structural protein 5B) is an RNA-dependant RNA polymerase responsible for replication of the hepatitis C viral genome, and is currently a principal target for chemotherapeutic inhibition of HCV replication. Hepatitis C virus (HCV) can cause chronic hepatitis, cirrhosis and hepatocellular carcinoma. At present there is no vaccine effective against HCV.
HCV 1a NS5; Hepatitis C virus NS5A; Non-structural protein 5A; p56; HCV genotype 1a NS5