HCV Active Nonstructural Protein 4 (DAG-P2774)

HCV Active Nonstructural Protein 4, recombinant protein from E. coli Datasheet

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Product Overview
Active hepatitis c virus Hepatitis C Virus NS4 protein fragment
Nature
Recombinant
Tag/Conjugate
Unconjugated
Cellular Localization
Endoplasmic reticulum; multi-pass membrane protein.
Bio-activity
Active hepatitis c virus Hepatitis C Virus NS4 protein fragment is immunoreactive with sera of HCV-infected individuals.
Purity
> 95 % by SDS-PAGE.This antigen was purified by a proprietary chromatographic technique.
Format
Liquid
Buffer
Preservative: None Constituents: 50% Glycerol, 1.5M Urea, 25mM Tris HCl, 1mM EDTA, pH 8.0
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze/thaw cycles.
Introduction
Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral protease
Antigen Description
NS4 A/B are two of the seven nonstructural (NS) proteins making up the HCV polyprotein. The NS proteins recruit the viral genome into an RNA replication complex, which is associated with rearranged cytoplasmic membranes. NS4A acts as a cofactor with the NS3 serine protease and stabilizes its folding. The NS3-NS4A complex is essential for the activation of the latter and allows membrane anchorage of NS3. HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV is responsible for a large proportion of worldwide chronic viral hepatitides. Most of these infections develop into chronic hepatitis, which often progresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis C infection. The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is a relatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
Keywords
HCV; HCV NS4; Hepatitis C Virus nonstructural antigen 4; Non structural protein 4A; Non structural protein 4B; NS4A; NS4B; p27; p8; HCV NS4

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