HIV type 1 Active Glycoprotein 120 (DAG-P2783)

HIV type 1 Active Glycoprotein 120, recombinant protein from E. coli Datasheet

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Product Overview
Active HIV1 gp120 + gp41 protein fragment
Nature
Recombinant
Tag/Conjugate
Unconjugated
Bio-activity
Active HIV1 gp120 + gp41 protein fragment is immunoreactive with all sera of HIV1 and HIV-type O infected individuals and with 60-80% of HIV2 infected individuals.
Purity
> 95 % by SDS-PAGE.
Format
Liquid
Buffer
Preservative: None Constituents: 0.5X PBS, 6M Urea
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. Preservative: None Constituents: 0.5X PBS, 6M Urea This product is an active protein and may elicit a biological response in vivo, handle with caution.
Introduction
The human immunodeficiency virus (HIV) is a lentivirus (slowly replicating retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic
Antigen Description
gp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes.
Keywords
Glycoprotein 120; Glycoprotein 41; HIV1 gp120; HIV1 gp41; SU; TM; HIV1 gp120 + gp41

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