EBV Active Nuclear Antigen (DAG-P2818)

EBV Active Nuclear Antigen, recombinant protein from E. coli

Product Overview
Active EBV Nuclear Antigen protein fragment
Cellular Localization
Nuclear. Free in the nucleoplasm, somewhat associated with the chromatin and hardly, if at all associated with the nuclear matrix.
This protein is immunoreactive with sera of EBV-infected individuals
> 95 % by SDS-PAGE.This protein was purified by proprietary chromatographic techniques.
Preservative: None Constituents: 50% Glycerol, 0.5% Sarkosyl, 60mM Sodium chloride, 50mM Tris HCl, 10mM Glutathione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze/thaw cycles.
The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is a virus of the herpes family, and is one of the most common viruses in humans.

It is best known as the cause of infectious mononucleosis (glandular fever). It is also associated wi
Antigen Description
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the one EBV antigen that is expressed in all EBV associated malignancies. It has long been thought to go undetected by the cell mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV related cancers.
EBNA1; EBV nuclear antigen 1; Epstein Barr nuclear antigen 1; Epstein Barr virus; HHV4; Human Herpesvirus 4; EBV Nuclear Antigen


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Paludan, C; Bickham, K; et al. Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cells. JOURNAL OF IMMUNOLOGY 169:1593-1603(2002).
Lemons-Estes, FM; Capt, HP; et al. A clonal cutaneous CD30+lymphoproliferative eruption in a patient with evidence of past exposure to hepatitis E. INTERNATIONAL JOURNAL OF DERMATOLOGY 39:521-527(2000).

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