E. coli Active Nitroreductase (DAG-P2710)

E. coli Active Nitroreductase (full length), recombinant protein from E. coli Datasheet

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Product Overview
Active E. coli Nitroreductase full length protein
> 90 % by SDS-PAGE.
Preservative: None Constituents: PBS, Lactose
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. Preservative: None Constituents: PBS, Lactose This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute the contents of the vial in 0.1ml water.
Escherichia coli; commonly abbreviated E. coli) is a gram-negative, facultatively anaerobic, rod-shaped bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms (endotherms). Most E. coli strains are harml
Antigen Description
Nitroreductase shows the ability to reduce quinines. It is an enzyme for activating prodrugs in antibody directed enzyme prodrug therapy. It is also capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species.
Dihydropteridine reductase; dprA; FMN dependent nitroreductase; nfnB; nfsI; ntr; Oxygen insensitive NAD(P)H nitroreductase; E. coli Nitroreductase; Escherichia coli Nitroreductase


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