Beta-2-Glycoprotein 1 Antigen (DAG-T1240)

Datasheet

Online Inquiry Add to basket

Product Overview
Purified from human plasma that has been tested and found to be negative for HIV, HCV and HBsAg antibodies. After coating onto ELISA plates the product will bind autoantibodies to β2-glycoprotein 1.
Target
APOH
Purity
The β2-glycoprotein 1 autoantigen (54 kDa) is more than 95% pure, as assessed by SDS gel electrophoresis.
Concentration
0.5-2.0 mg/ml
Size
1.0 mg
Storage
The product is stabilised with 20% glycerol and 0.1% Micr-O-protect TM. Store at -20°C or below (long term) or at +4°C (short term). Avoid repeated freezing and thawing. Mix thoroughly before use.
UniProt ID
Antigen Description
Apolipoprotein H (Apo-H), previously known as (β2-glycoprotein I, beta-2 glycoprotein I), is a multifunctional apolipoprotein. One of its functions is to bind cardiolipin. When bound the structure of cardiolipin and Apo-H both undergo large changes in structure. Within the structure of Apo-H is a stretch of positively charged amino acids, (protein sequence positions 282-287) Lys-Asn-Lys-Glu-Lys-Lys, are involved in phospholipid binding (See image on right).
Apo-H has a complex involvement in agglutination, it appears to alter ADP mediated agglutination of platelets. Normally Apo-H assumes an anti-coagulation activity in serum (by inhibiting coagulation factors), however changes in blood factors can result of a reversal of that activity.
Function
eukaryotic cell surface binding; glycoprotein binding; heparin binding; lipid binding; lipoprotein lipase activator activity; phospholipid binding; protein binding;
Synonyms
APOH; apolipoprotein H (beta-2-glycoprotein I); B2G1; beta-2-glycoprotein 1; beta 2 glycoprotein I; BG; B2GPI; apo-H; beta(2)GPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein; B2GP1;

Citations


Have you cited DAG-T1240 in a publication? Let us know and earn a reward for your research.

Related Products


Customer Reviews


Write a review, share your experiences with others and get rewarded !

Online Inquiry

Name
Phone *
E-mail Address *
Service & Products Interested *
Project Description
Verification Code * Please input "diagnostics" as verification code.

Online Inquiry

Order Info: Beta-2-Glycoprotein 1 Antigen

Online Inquiry
  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!
  15% off your first purchase

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket